Rybelsus - Semaglutide

What is it?

Composition

The composition of the drug Rybelsus is based on the active substance semaglutide, which is an analogue of glucagon-like peptide-1 (GLP-1). Semaglutide helps control blood sugar levels by affecting the mechanisms involved in glucose regulation. In addition, each tablet contains auxiliary components that ensure its stability and absorption.

The main ingredients can be divided into active and auxiliary substances. Semaglutide performs the main therapeutic function, and auxiliary elements maintain the stability and ease of use of the drug.

• Semaglutide is the active ingredient responsible for lowering blood sugar levels.
• Microcrystalline cellulose is an auxiliary substance that provides the structure of the tablet.
• Magnesium stearate is a component that improves the shape of the tablet and prevents it from disintegrating before administration.
• Other inert substances are added for stability and ease of swallowing.

How to use?

Rybelsus should be taken strictly as prescribed by your doctor to ensure maximum effectiveness and avoid side effects. The drug is available in tablet form, which are taken orally once a day, preferably at the same time.

For correct use, follow these recommendations:

1. Take the tablet in the morning on an empty stomach with a small amount of water (about 120 ml). Do not use other drinks.
2. After taking the drug, do not eat or drink anything for at least 30 minutes to ensure proper absorption of the medicine.
3. Swallow the tablet whole, without chewing or breaking it, as this may affect the effectiveness.
4. The dosage is prescribed by the doctor individually. As a rule, treatment begins with a minimum dose, gradually increasing it to the optimal one.

It is important to follow the doctors instructions and not exceed the prescribed dosage. If you forget to take a tablet, do not double the dose; just take the next one on schedule.

How does it work?

The mechanism of action of Rybelsus is based on the effect of its active substance, semaglutide, on the receptors of glucagon-like peptide-1 (GLP-1). This hormone plays a key role in regulating blood sugar levels. Semaglutide acts by imitating the work of natural GLP-1, which helps to strengthen control over glucose levels.

After taking Rybelsus, several processes are activated in the body:

Insulin secretion increases in response to increased sugar levels, which helps cells absorb glucose.

The production of glucagon, a hormone that stimulates the formation of glucose in the liver, decreases.
Slows down gastric emptying, which promotes more uniform absorption of carbohydrates and reduces sharp jumps in sugar after meals.
This comprehensive approach helps to reduce blood sugar levels both on an empty stomach and after meals. Due to the peculiarities of action, the drug can also contribute to weight loss in some patients.

Indications

Rybelsus is used to treat adults with type 2 diabetes when diet and physical activity do not provide sufficient control of blood sugar levels. Its use is aimed at improving the general condition of the patient and reducing the risk of complications associated with diabetes.

Main indications for use:

• Type 2 diabetes to improve blood sugar control.
• Reducing the risk of cardiovascular events in patients with type 2 diabetes and a high risk of such diseases.
• Maintaining blood sugar levels in patients who have not achieved sufficient control with other drugs or approaches.

Rybelsus is used both as monotherapy and in combination with other antidiabetic agents, including insulin. Before starting use, it is necessary to discuss all the features of the treatment with your doctor to determine whether the drug is suitable for your specific situation.

Contraindications

Rybelsus has a number of contraindications that should be considered before starting treatment. The use of the drug may be unsafe for some groups of patients, so it is important to consult a doctor and inform about any chronic diseases or other conditions.

Main contraindications:

• Allergy or hypersensitivity to semaglutide or any of the excipients of the drug.
• Type 1 diabetes or diabetic ketoacidosis.
• Severe liver or kidney dysfunction, if they interfere with the proper elimination of the drug from the body.
• History or suspicion of thyroid cancer or tumors in the endocrine organs, including multiple endocrine neoplasia syndrome type 2 (MEN-2).
• Pregnancy or breastfeeding.

Side effects

Like any medicine, Rybelsus can cause side effects, although not everyone gets them. Most side effects are related to the effects of semaglutide on the digestive system, but other effects are possible.

The most common side effects include:

• Nausea, which usually decreases as your body adjusts to the drug.
• Diarrhea or, conversely, constipation.
• Pain or discomfort in the abdomen.
• Loss of appetite, which can contribute to weight loss.

Rarely, serious side effects may occur, such as:

• Problems with the pancreas (such as pancreatitis), accompanied by severe pain in the abdomen.
• Hypersensitivity reactions, including rash, itching, or swelling.
• Impaired kidney function, especially in the presence of chronic kidney disease.