Celebrex

What is it?

Composition

Celebrex is available in capsules containing the active substance celecoxib. Each component of the formula is carefully selected to ensure the stability, safety and effectiveness of the drug.

• Active substance: celecoxib. Its concentration depends on the form of release, most often it is 100 mg or 200 mg per capsule.
• Excipients: lactose, sodium croscarmellose, magnesium stearate, povidone and sodium lauryl sulfate. These components ensure the stability of the drug, as well as its convenient and safe use.
• Capsule shell: gelatin and titanium dioxide (E171), which give the capsule a characteristic white or slightly creamy color.

This composition allows the drug to be quickly released and act on the body, providing an effective reduction in inflammation and pain. It is important to take into account that the composition of excipients may vary slightly depending on the manufacturer.

How to use?

Proper use of Celebrex is very important to achieve the maximum therapeutic effect and minimize the risk of side effects. Before starting treatment, be sure to consult with your doctor and follow his recommendations.

1. Dosage regimen: The usual starting dose is 200 mg per day. It can be taken either once (200 mg) or divided into two doses (100 mg twice a day). The specific dosage is determined depending on the diagnosis, the patients condition and tolerability of the drug.
2. Method of administration: The capsules are taken orally with a sufficient amount of water. The drug can be taken with or without food, but taking it with food can reduce the risk of stomach irritation.
3. Duration of treatment: The course of treatment is determined by the doctor. You should not take the medicine longer than recommended or in higher doses than prescribed.

If you miss a dose, take it as soon as you remember, but do not double the next dose. Follow the prescribed schedule to ensure a stable level of the medicine in your body.

How does it work?

Celebrex works by inhibiting the activity of the enzyme cyclooxygenase-2 (COX-2), which plays a key role in the synthesis of prostaglandins. Prostaglandins are substances that cause inflammation, pain, and an increase in body temperature. Due to the specific effect on COX-2, the drug effectively reduces inflammation and reduces pain.

Unlike most other non-steroidal anti-inflammatory drugs (NSAIDs), Celebrex selectively inhibits COX-2, with minimal effect on COX-1. COX-1 is involved in protecting the gastric mucosa and maintaining platelet function. Due to this selective action, Celebrex reduces the likelihood of gastrointestinal complications, such as ulcers or bleeding, which often accompany the use of traditional NSAIDs.

This mechanism makes the drug especially useful for patients suffering from chronic inflammatory diseases that require long-term treatment. However, it is important to remember that Celebrex does not eliminate the cause of inflammation, but only alleviates its symptoms.

Indications

Celebrex is used to treat various inflammatory and painful conditions. It is indicated for the following diseases and conditions:

• Osteoarthritis is a chronic joint disease characterized by the destruction of cartilage tissue, pain, and limited mobility.
• Rheumatoid arthritis is an autoimmune disease that causes inflammation, pain, and damage to the joints.
• Ankylosing spondylitis is a chronic inflammation of the spine and joints that leads to stiffness and pain in the back.
• Acute pain of various origins, including postoperative or post-traumatic pain syndrome.
• Primary dysmenorrhea is severe pain in the lower abdomen during menstruation.

Celebrex is especially effective in cases where long-term treatment is required with a minimal risk of complications from the gastrointestinal tract. However, the prescription of the drug must be justified by a doctor, based on the diagnosis and general condition of the patient.

Contraindications

Despite its effectiveness, Celebrex is not suitable for all patients. There are certain medical conditions and circumstances in which the use of this drug is contraindicated:

• Hypersensitivity or allergy to celecoxib or any of the excipients included in the drug.
• Allergic reactions to other non-steroidal anti-inflammatory drugs (eg, aspirin or ibuprofen), including bronchospasm, urticaria, or angioedema.
• Severe liver or kidney disease, including decompensated liver failure.
• Cardiovascular diseases, such as severe heart failure, ischemic heart disease, or recent myocardial infarction.
• Acute gastric or duodenal ulcers, as well as gastrointestinal bleeding.
• Pregnancy, especially the third trimester, and the period of breastfeeding breastfeeding.
• Children under 18 years of age (depending on the form of release and the manufacturers recommendations).

The use of Celebrex should be strictly agreed upon with a doctor, especially if the patient has concomitant diseases or risk factors. If there are any doubts or questions, it is recommended to discuss all the details with the attending specialist.

Side effects

Like any medication, Celebrex can cause side effects. Their frequency and severity depend on the individual characteristics of the patients body, the duration of treatment and dosage.

• From the digestive system: nausea, dyspepsia, diarrhea, abdominal pain, flatulence. Less common: stomach or duodenal ulcers, gastrointestinal bleeding.
• Cardiovascular system: increased blood pressure, edema, in rare cases - thrombosis, myocardial infarction or stroke.
• Allergic reactions: skin rash, itching, urticaria, angioedema, anaphylaxis (very rare).
• Nervous system: headache, dizziness, insomnia or, conversely, drowsiness.
• Respiratory system: nasal congestion, pharyngitis, cough.

If the patient experiences adverse reactions while taking Celebrex, it is necessary to stop using the drug and consult a doctor. Particular caution should be exercised in patients at risk of cardiovascular and gastrointestinal complications.